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. 2018 Sep 26;19(10):2925. doi: 10.3390/ijms19102925

Figure 4.

Figure 4

JMV2959 pretreatment effects on active lever-pressing during the methamphetamine intravenous self-administration (IVSA). JMV2959 3 mg/kg or saline were administered i.p. 20 min before the sessions. In the graph (a) active lever-pressings within daily 3 h sessions are illustrated during the last week before pretreatments, during the three pretreatment days and during the relapse-like behavior testing on the 12th day of abstinence, when the rats were not connected to the infusion pump. The mean of the last three baselines before the pretreatment (5–7 bas) was used for statistical analysis by two-way ANOVA for repeated measures (RM). Means of the rat groups are presented ± SEM; N = 12 (JMV2959 group), N = 8 (saline group). In the graph, (b) mean JMV2959/saline active lever-pressing (1–3 JMV/sal) are illustrated together with the mean baselines (5–7 bas). All of the data of the three last baselines and the three pretreatments were used for two-way ANOVA analysis. The effects are shown as follows: saline (open circle, open bar), JMV2959 (filled circle, filled bar). Differences between the groups are expressed as # p < 0.05, ### p < 0.001. Differences to baseline mean are expressed as *** p < 0.001, and the horizontal arrow shows the two appropriate bars.