Skip to main content
. 2018 Sep 26;19(10):2925. doi: 10.3390/ijms19102925

Figure 8.

Figure 8

JMV2959 pretreatment effects on methamphetamine consumption/dose mg/kg during the IVSA. JMV2959 3 mg/kg or saline were administered i.p. 20 min before the sessions. In the graph, (a) methamphetamine intake mg/kg within daily 3 h sessions are illustrated during the last week before pretreatments and during the three pretreatment days. The mean of the last three baselines before the pretreatment (5–7 bas) was used for statistical analysis with two-way ANOVA RM. The means of the groups are presented ± SEM; N = 12 (JMV2959 group), N = 8 (saline group). In the graph (b) the mean JMV2959/saline effects (1–3 JMV/sal) are illustrated together with the mean baselines (5–7 bas); two-way ANOVA was used for statistical analysis. The effects are shown as follows: saline (open circle, open bar), JMV2959 (filled circle, filled bar). Differences between the groups are expressed as # p < 0.05, ### p < 0.001. Differences to baseline mean are expressed as ** p < 0.01, *** p < 0.001, the horizontal arrow shows the two appropriate bars.