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. 2018 Sep 26;19(10):2925. doi: 10.3390/ijms19102925

Figure 9.

Figure 9

Changes of inactive lever-pressing during the methamphetamine IVSA and JMV2959 pretreatments. JMV2959 3 mg/kg or saline were administered i.p. 20 min before the sessions. In the graph (a) inactive lever-pressings within daily 3 h sessions are illustrated during the last week before pretreatments, during the three pretreatment days and during the relapse-like behavior testing on the 12th day of abstinence, when the rats were not connected to the infusion pump. Mean of the last three baselines before the pretreatment (5–7 bas) was used for statistical analysis by two-way ANOVA RM. Means of the rat groups are presented ± SEM; N = 12 (JMV2959 group), N = 8 (saline group). In the graph, (b) the mean JMV2959/saline inactive lever-pressing (1–3 JMV/sal) are illustrated together with the mean baselines (5–7 bas); two-way ANOVA was used for analysis. The effects are showed as follows: saline (open circle, open bar), JMV2959 (filled circle, filled bar). Differences between groups are expressed as ## p < 0.01. Differences to baseline mean are expressed as * p < 0.05, the horizontal arrow shows the two appropriate bars.