Table 1.

Changes of rat body mass within the IVSA study. The body mass changes are represented as group means (JMV2959 group N = 12, Saline group N = 8) during the chosen periods of the experiment as follows: mean of the last eight days before pretreatment (Bas mean), mean of the three pretreatment days (JMV/sal mean), the day of the relapse-like behavior test (Rel behav), mean of 8 baseline days + 3 pretreatment days + day of relapse-behavior testing (Total mean). Means of the rat groups are presented ± SEM. The statistical significances are described below the table.

Changes of Rat Body Mass within the IVSA Study-Group Means (g ± SEM)
Group/interval	Bas mean	JMV/sal mean	Rel behav	Total mean
JMV2959 group	286.7 ± 3.3	289.1 ± 6.3	351.0 ± 12.6	292.3 ± 7.3
Saline group	293.2 ± 5.3	298.1 ± 6.1	361.4 ± 18.4	300.1 ± 6.0

Two-way ANOVA RM difference between JMV2959 vs. saline groups: F1,18 = 0.43, p = 0.519 (n.s.), effect of time: F11,198 = 33.45, p < 0.001 (difference of relapse-like behavior in both JMV2959 and saline groups vs. other parameters), time × group interaction: F11,198 = 0.17, p = 0.1 (n.s.); Baseline = mean of 8 days, JMV/sal = mean of 3 pretreatment days, Relapse-like behavior = 1 day, Total mean = 8 Bas + 3 JMV/sal + Rel behav = 12 days; JMV2959 group N = 12, Saline group N = 8.