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. 2018 Oct 4;19(10):3030. doi: 10.3390/ijms19103030

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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MUC16/CA125-positive labeling of EOC cells in mouse tissues and tumor foci in IP-inoculated nude mice (MUC 16/CA 125, scale bar: 50 µm): (a) Negative tissue control (normal mouse liver). MUC16/CA125 immunolabeling, DAB chromogen, hematoxylin counterstain; (b) IP-ovarian carcinoma infiltrating skeletal myofibrils (stars) of the body wall. EOC cell-associated (yellow arrow) and extracellular (red arrows) MUC16-positive labeling. MUC16/CA125 immunolabeling, DAB chromogen, hematoxylin counterstain; (c) IP-inoculated ovarian carcinoma infiltrating the pancreas (stars) with MUC16-positive labeling of cytoplasmic membranes (arrows) and extracellular (* asterisks) labeling of neoplastic cells. MUC16/CA125 immunolabeling, DAB chromogen, hematoxylin counterstain.