Table 2.
The expression changes of sirtuins in neurological diseases and animal models.
| Sirtuins | Sirtuin expression changes (increase/decrease) | RNA or protein | Location of expression changes | Human or mouse | Disease or animal model | Reference |
|---|---|---|---|---|---|---|
| SIRT2 | Decrease | Protein | Cultured cerebellar granule cells from Wlds mice | Mouse | Wlds | Suzuki and Koike, 2007 |
| SIRT1 | Decrease | Protein | Spinal cord | Mouse | SCI | Chen, 2017 |
| SIRT1 | Increase | Protein | Injured-side cortex | Mouse | TBI | Zhao, 2012 |
| SIRT1 | Increase | Protein | Cortex | Rat | SAH | Zhang, 2016 |
| SIRT1 | Increase | Protein | Peri-infarct regions of injured-side cortex | Mouse | MCAO | Hernandez-Jimenez, 2013 |
| SIRT1 | Increase | Protein | Acute and chronic active lesion in MS brain CD4+, CD68+, GFAP+, oligodendrocytes | Human | MS | Tegla, 2013 |
| SIRT1 | Increase | Protein | GFAP+ cells in typical inflammatory perivascular cuffs in brain | Mouse | EAE | Prozorovski, 2008 |
| SIRT1 | Decrease | Protein, mRNA | Parietal cortex | Human | AD | Julien, 2009 |
| SIRT3 | Decrease | Protein | Frontal cortex | Human | AD | Lee, 2018 |
| SIRT6 | Decrease | Protein | Temporal cortex | Human | AD | Kaluski. 2017 |
| SIRT1 | Increase | Protein | Forebrain | Mouse | AD | Kim, 2007 |
| SIRT1 | Decrease | Protein | Frontal cortex | Human | PD | Singh, 2017 |
| SIRT1 (80 kDa) | Increase | Protein | Temporal cortex | Human | PD | Singh, 2017 |
| SIRT1 | Increase | Protein | Spinal cord | SOD1G37R mouse | ALS (severe neurodegeneration) | Kim, 2007 |
| SIRT3 | Decrease | mRNA | Spinal cord, brain stem | SOD1 G93A mouse | ALS (end stage) | Buck, 2017 |