Different scaffolds used as in vivo patches or augmentations for tendon and ligament tissue engineering. (a) Microfiber SE knitted scaffolds, mounted on a drum collector, and covered by nanofibers of PLLGA loaded with bFGF (adapted from Sahoo et al. [84], reproduced with permission. Copyright 2010, Elsevier): (I–II) SEM images of nanofibers at different magnifications (arrows point bFGFs particles); (III) SEM image of nanofibers (eF) and SE microfibers (μF); and (IV–V) images of the complete scaffold before (IV) and after (V) twisting. (b) Multilayer scaffold for tendon repair, made of a woven layer of PCL monofilament and electrospun nanofibers mats of random nanofibers of PCL and aligned PDO nanofibers, obtained using a drum collector at different rotation speeds (adapted from Hakimi et al. [106], reproduced with permission. Copyright 2015, Elsevier): (I) schematic assembly procedure; (II–VIII) SEM images of the scaffold and mats ((IV–VIII) scale bar = 100 micrometers); and (IX) explanation of the different mats functions.