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. 2018 Oct 20;10(10):1558. doi: 10.3390/nu10101558

Table 5.

Univariate and multivariate linear regression analysis in Men and Women separately.

Men
SSAR1_N C20:0 Arachidic Acid
SSAR1_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.235 6e-7 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.161 0.002 −0.004 0.010 0.002 0.94 −0.003 0.025 −0.001 0.64 --- --- --- --- --- ---
model2 −0.161 0.002 −0.004 0.011 0.002 0.95 −0.003 0.025 −0.001 0.64 −0.001 0.94 --- --- --- ---
model3 −0.154 0.003 −0.004 0.007 0.002 0.94 −0.003 0.038 −0.0004 0.92 −0.001 0.91 −0.007 0.36 --- ---
model4 −0.167 0.004 −0.004 0.009 0.0004 0.99 −0.003 0.036 −0.001 0.84 −0.001 0.92 −0.008 0.33 6.6e-5 0.60
SSDA1_N C22:0 Docosanoic Acid
SSDA1_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.182 6e-5 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.125 0.012 −0.004 0.008 −0.002 0.94 −0.003 0.016 −0.002 0.48 --- --- --- --- --- ---
model2 −0.126 0.012 −0.004 0.008 −0.002 0.93 −0.003 0.017 −0.002 0.49 −0.003 0.77 --- --- --- ---
model3 −0.123 0.014 −0.004 0.004 −0.002 0.95 −0.003 0.029 −0.001 0.84 −0.003 0.74 −0.009 0.23 --- ---
model4 −0.121 0.017 −0.004 0.007 −0.001 0.98 −0.003 0.030 −0.0004 0.91 −0.003 0.74 −0.008 0.33 −5.5e-5 0.64
SSARA_N C20:4 n-6 Arachidonic Acid (AA)
SSARA_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.178 4e-5 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.119 0.018 −0.004 0.008 0.012 0.65 −0.003 0.039 −0.002 0.53 --- --- --- --- --- ---
model2 −0.119 0.018 −0.004 0.008 0.012 0.65 −0.003 0.039 −0.002 0.53 0.0002 0.98 --- --- --- ---
model3 −0.115 0.022 −0.004 0.005 0.012 0.64 −0.002 0.064 −0.0004 0.90 −0.0002 0.98 −0.01 0.21 --- ---
model4 −0.117 0.026 −0.004 0.008 0.012 0.65 −0.002 0.062 −0.0004 0.91 −0.0002 0.98 −0.009 0.28 −1.9e-5 0.88
SSDTA_N C22:4 n-6 Docosatetraenoic Acid (DTA)
SSDTA_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.123 3e-4 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.084 0.021 −0.004 0.004 0.011 0.66 −0.003 0.027 −0.002 0.50 --- --- --- --- --- ---
model2 −0.084 0.021 −0.004 0.004 0.011 0.67 −0.003 0.027 −0.002 0.50 −0.001 0.93 --- --- --- ---
model3 −0.077 0.039 −0.005 0.003 0.010 0.68 −0.002 0.041 −0.001 0.76 −0.001 0.91 −0.007 0.35 --- ---
model4 −0.088 0.045 −0.005 0.004 0.010 0.68 −0.003 0.039 −0.001 0.70 −0.001 0.91 −0.008 0.34 5.6e-5 0.68
Women
SSAR1_N C20:0 Arachidic Acid
SSAR1_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.098 0.21 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.097 0.30 −0.002 0.37 0.025 0.59 −0.003 0.18 −0.008 0.051 --- --- --- --- --- ---
model2 −0.092 0.33 −0.002 0.35 0.026 0.57 −0.003 0.21 −0.008 0.08 −0.019 0.61 --- --- --- ---
model3 −0.090 0.36 −0.002 0.33 0.027 0.57 −0.003 0.22 −0.007 0.13 −0.013 0.73 −0.007 0.64 --- ---
model4 −0.105 0.33 −0.002 0.37 0.026 0.58 −0.003 0.21 −0.008 0.12 −0.016 0.69 −0.009 0.59 1e-4 0.74
SSDA1_N C22:0 Docosanoic Acid
SSDA1_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.165 0.022 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.113 0.17 −0.002 0.43 0.030 0.52 −0.003 0.18 −0.009 0.029 --- --- --- --- --- ---
model2 −0.122 0.14 −0.002 0.42 0.031 0.51 −0.003 0.23 −0.008 0.06 −0.030 0.42 --- --- --- ---
model3 −0.121 0.15 −0.002 0.40 0.031 0.50 −0.003 0.24 −0.008 0.10 −0.024 0.54 −0.007 0.65 --- ---
model4 −0.126 0.15 −0.002 0.42 0.032 0.51 −0.003 0.23 −0.008 0.10 −0.027 0.51 −0.008 0.62 1e-4 0.80
SSARA_N C20:4 n-6 Arachidonic Acid (AA)
SSARA_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.147 0.017 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.15 0.038 −0.002 0.32 0.043 0.33 −0.003 0.21 −0.007 0.10 --- --- --- --- --- ---
model2 −0.147 0.042 −0.002 0.30 0.044 0.32 −0.003 0.25 −0.006 0.15 −0.018 0.61 --- --- --- ---
model3 −0.148 0.045 −0.002 0.30 0.044 0.33 −0.003 0.25 −0.006 0.20 −0.016 0.67 −0.003 0.84 --- ---
model4 −0.163 0.040 −0.002 0.34 0.045 0.31 −0.003 0.21 −0.006 0.17 −0.021 0.59 −0.005 0.75 2e-4 0.59
SSDTA_N C22:4 n-6 Docosatetraenoic Acid (DTA)
SSDTA_N (log) Age (yr) Smoking (Y/N) dBP BMI CRP HOMA_IR TG
β p β p β p β p β p β p β p β p
model0 −0.043 0.40 --- --- --- --- --- --- --- --- --- --- --- --- --- ---
model1 −0.093 0.11 −0.003 0.19 0.046 0.31 −0.003 0.23 −0.007 0.11 --- --- --- --- --- ---
model2 −0.090 0.13 −0.003 0.18 0.046 0.31 −0.003 0.25 −0.006 0.14 −0.013 0.72 --- --- --- ---
model3 −0.089 0.14 −0.003 0.18 0.046 0.31 −0.003 0.26 −0.006 0.18 −0.011 0.77 −0.003 0.84 --- ---
model4 −0.129 0.09 −0.003 0.23 0.052 0.26 −0.003 0.18 −0.007 0.13 −0.017 0.66 −0.006 0.69 4e-4 0.37

The effects of various combinations of potential confounding factors were adjusted with multivariate models as follows: Model 0: log VO2max ~ log FA (univariate analysis); Model 1: log VO2max ~ log FA + Age + Smoking + dBP + BMI; Model 2: log VO2max ~ log FA + Age + Smoking + dBP + BMI + CRP; Model 3: log VO2max ~ log FA + Age + Smoking + dBP + BMI + CRP + HOMA-IR; Model 4: log VO2max ~ log FA + Age + Smoking + dBP + BMI + CRP + HOMA-IR + TG; Abbreviations: dBP: diastolic Blood Pressure (mmHg); BMI: Body Mass Index (kg/m2); CRP: Plasma C-Reactive Protein (mg/dL); β: coefficient of variable; HOMA_IR: HOmeostatic Model Assessment – Insulin Resistance; TG: Plasma Triglyceride (mg/dL).