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. 2018 Oct 11;19(10):3116. doi: 10.3390/ijms19103116

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthetic pathways for compounds 3a–o and 4a–o. Reagents and conditions: (a) epibromohydrin, acetone, 60 °C reflux 4 h; (b) aromatic primary amines, Zn(ClO₄)₂·6H₂O, EtOH, 80 °C, reflux 1 h; (c) BTC (bis(trichloromethyl)carbonate), NaOH, THF (tetrahydrofuran), DCM, 2 h.