TABLE 2: .
Select antidepressant dosing and adverse effects1,10,13,20,34
|
Starting Dose |
Effective Dose, mg |
Maximum Dose, mg |
|
| Selective serotonin reuptake inhibitors | |||
| Citalopram | 10 mg/d | 20 | 40 |
| Escitaloprama | 5 mg/d | 10-20 | 20 |
| Fluoxetineb | 5-10 mg/d | 10 | 40 |
| Fluvoxamine | 25 mg/d | 150 | 300 |
| Paroxetinec | 10 mg/d | 10 | 20 |
| Sertraline | 25 mg/d | 50 | 200 |
| Serotonin norepinephrine reuptake inhibitors | |||
| Duloxetine | 20-30 mg/d | 30-60 | 60 |
| Venlafaxine | 12.5-25 mg/d | 37.5-75 | 150-225 |
| Miscellaneous agents | |||
| Bupropion | 75 mg/d | 75-150 | 150-300 |
| Mirtazapine | 15 mg/night | 15-30 | 15-45 |
a
Food and Drug Administration approved for depression in adolescents 12-17 years of age.
b
Food and Drug Administration approved for depression in children and adolescents 8-17 years of age.
c
Should be avoided in youth due to increased risk of suicidality compared with other antidepressants.