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. 2018 Nov 1;8(6):275–283. doi: 10.9740/mhc.2018.11.275

TABLE 3: .

General treatment guidelines15,19,34

Stages of Treatment
Severity of Depression
Treatment Recommendations
1 Mild to moderate Cognitive behavioral therapy
Interpersonal psychotherapy-adolescents
Acceptance and commitment therapy
Mindfulness-based cognitive therapy
Family interventions
Moderate to severe First-line
 Selective serotonin reuptake inhibitors
 Serotonin norepinephrine reuptake inhibitors
 Norepinephrine dopamine reuptake inhibitor
 Noradrenaline and specific serotonergic antidepressant
Second-line
 Tricyclic antidepressants
 Monoamine oxidase inhibitors
2 Combination therapy (medication + therapy)
Increase antidepressant dose
Augment antidepressant with lithium ± antipsychotic
Antidepressant combination
Repetitive transcranial magnetic stimulation
3 Electroconvulsive therapy