(B)
| Parameter | Borderline Subjects (#) | Day 1 | Day 75 | % Reduction | p Value |
|---|---|---|---|---|---|
| FBG (mg/dL) | 1; 4; 9; 10 | 99 ± 5.7 | 69 ± 11.3 | 30.2 ± 8.7 | 0.003 |
| HbA1c (%) | 1; 5; 7 | 5.7 ± 0.2 | 5.2 ± 0.2 | 8.1 ± 4.7 | 0.050 |
| TC (mg/dL) | 1; 2; 3; 4; 7; 8; 9 | 217 ± 18.3 | 175 ± 21 | 19.3 ± 7.8 | <0.001 |
| Non-HDL-C (mg/dL) | 1; 2; 3; 4; 7; 8 | 163 ± 10 | 119 ± 16 | 26.6 ± 10.4 | 0.001 |
| BMI (Kg/m2) | 2; 5; 8 | 25.2 ± 0.9 | 24.0 ± 0.7 | 4.5 ± 0.3 | 0.002 |
| Waist circumference (cm) | 2; 4; 5 | 96.0 ± 7.9 | 87.0 ± 7.1 | 9.0 ± 4.2 | 0.034 |
| Cardiovascular risk | 2; 3; 4;6; 7; 8 | 4.1 ± 0.4 | 3.2 ± 0.3 | 21.2 ± 11.0 | 0.005 |
Mean ± SD values of each parameter were calculated separately in “normal” (panel A) subjects (unshaded in Table 3) and in borderline subjects (panel B), i.e., those with starting values of FBG ≥ 96 mg/dL, HbA1c ≥ 5.6%, TC > 200 mg/dL, non-HDL-C ≥ 154 mg/dL; BMI > 24 Kg/m2, waist circumference ≥ 90 cm (grey-shaded in Table 3). p by paired, one-tailed t-test; n.s., not significant. FBG, fasting blood glycemia; HbA1c, glycated hemoglobin; TC, total cholesterol.