Table 2.
Fatty acid profile in mouse brain tissue.
| Fatty Acids mg/g Tissue | Saline | LPS | Statistical Effects | ||||
|---|---|---|---|---|---|---|---|
| WT N = 11 | Fat-1 N = 11 | WT N = 11 | Fat-1 N = 10 | LPS | Genotype | LPS × Genotype | |
| EPA (20:5 n-3) | 0.17 ± 0.03 | 0.33 ± 0.05 * | 0.18 ± 0.04 | 0.27 ± 0.03 | NS | <0.01 | NS |
| DPA (22:5 n-3) | 0.19 ± 0.04 | 0.27 ± 0.03 | 0.23 ± 0.04 | 0.29 ± 0.05 | NS | NS | NS |
| DHA (22:6 n-3) | 2.65 ± 0.07 | 3.08 ± 0.05 *** | 2.76 ± 0.04 | 3.15 ± 0.10 ## | NS | <0.001 | NS |
| Subtotal n-3 | 3.01 ± 0.11 | 3.59 ± 0.13 ** | 3.18 ± 0.69 | 3.71 ± 0.11 ## | NS | <0.001 | NS |
| LA (18:2 n-6) | 0.38 ± 0.03 | 0.52 ± 0.05 | 0.50 ± 0.06 | 0.48 ± 0.05 | NS | NS | NS |
| DGLA (20:3 n-6) | 0.12 ± 0.01 | 0.16 ± 0.02 * | 0.015 ± 0.01 | 0.16 ± 0.01 | NS | <0.05 | NS |
| AA (20:4 n-6) | 1.56 ± 0.05 | 1.55 ± 0.06 | 1.60 ± 0.04 | 1.58 ± 0.08 | NS | NS | NS |
| Subtotal n-6 | 2.06 ± 0.05 | 2.21 ± 0.07 | 2.26 ± 0.07 | 2.19 ± 0.08 | NS | NS | NS |
| n-3/n-6 | 1.46 ± 0.04 | 1.68 ± 0.06 | 1.42 ± 0.07 | 1.68 ± 0.03 # | NS | <0.001 | NS |
| AA/DHA | 0.59 ± 0.01 | 0.51 ± 0.02 ** | 0.58 ± 0.01 | 0.50 ± 0.02 ## | NS | <0.001 | NS |
AA: arachidonic acid; DHA: docosahexaenoic acid; DGLA: dinomo-γ-linolenic acid; DPA: docosapentaenoic acid; EPA: eicosapentaenoic acid; LA: linolcic acid; LPS: lipopolysaccharides; NS: no significance. Data are mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. wild-type (WT)/saline; # p < 0.05, ## p < 0.01 vs. WT/LPS.