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. 2018 Sep 29;19(10):2981. doi: 10.3390/ijms19102981

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The Evaluation of cytosolic and serum high mobility group box 1 (HMGB1) in 5-FU-induced oral mucositis. (A) Immunohistochemical analysis of cytosolic HMGB1 expression in the oral mucosa. The number of HMGB1-positive cells per field in the lesion have been count. * p < 0.05 vs. 500 mg/kg ANT-rich extract fed with 5-FU injection, # p < 0.001 vs. DI fed with normal saline (NS) injection; (B) serum HMGB1 levels were evaluated by ELISA. Data are expressed as the mean ± S.D. (n = 6). * p < 0.001 vs. 1000 mg/kg ANT-rich extract fed with 5-FU injection; (C) Correlation of the levels of collagen in the buccal mucosa and serum HMGB1.