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The critical roles of FOXM1 in cancer progression. (A) Integration of extracellular and intracellular signaling pathways with the axis of forkhead box protein M1 and forkhead box class O3a. (B) FOXM1 contributes to chemo-resistance through ABC transporters, tumor growth and cell proliferation through cell-cycle, cancer cell metastasis through matrix metalloproteinases, and DNA damage response through NBS1.
