Table 1.

Clinical features of tuberous sclerosis and Sotos syndrome.

Features	Sotos Syndrome	Tuberous Sclerosis
Somatic overgrowth	+++	−
Macrocephaly	++	−
Facial findings	++	−
Brain malformations	++	++
Seizures	+/−	+++
Increased tumorigenesis	++	++
Multiple Hamartomas	−	++
Hypomelanotic macules	−	+++
Learning disabilities	++	++

+++, very frequent; ++, frequent; +/−, rare; −, absent.