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Schematic diagram showing the activation of the non-selective cation channels, transient receptor potential canonical (TRPC-1), increasing calcium (Ca2+) influx into the vascular smooth muscle cells (VSMC) and endothelial cells. Displayed data suggests that calcium influx induces the upregulation of endothelial nitric oxide synthase (e-NOS) and nitric oxide (NO) release, promoting endothelial protective effects.
