Table 4.
IL-8 plasma levels and polymorphisms in IL-8 and CXCR2 genes *.
| SNPs Genotypes | IL-8 Levels, Median [IQR] in pg/mL | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-Periodontitis HC N = 32 (%) |
HC+CP N = 41 (%) |
T1DM+CP N = 36 (%) |
T2DM+CP N = 43 (%) |
T2DM+CP Subgroups | |||||||||
| Well/Satisfactorily Controlled N = 16 (%) |
Unsatisfactorily Controlled N = 27 (%) |
||||||||||||
|
IL-8 (−251A/T, rs4073) |
TT | 10 (31.3) |
9.20 [8.61–11.86] |
10 (24.4) |
10.36 [6.47–13.60] |
11 (30.6) |
13.16 [10.43–19.67] |
16 (37.2) |
13.75 [10.73–25.39] |
5 (31.3) |
12.87 [12.29–24.63] |
11 (40.7) |
14.33 [9.16–26.14] |
| AT | 15 (46.9) |
11.00 [7.52–12.87] |
21 (51.2) |
7.68 [5.66–15.17] |
16 (44.4) |
17.38 [7.01–20.92] |
17 (39.5) |
14.18 [11.43–16.54] |
6 (37.4) |
15.10 [9.86–20.27] |
11 (40.7) |
13.49 [11.43–16.54] |
|
| AA | 7 (21.8) |
10.86 [8.61–12.66] |
10 (24.4) |
12.19 [8.88–16.24] |
9 (25.0) |
13.33 [10.86–22.70] |
10 (23.3) |
15.80 [12.33–23.13] |
5 (31.3) |
16.69 [15.36–23.13] |
5 (18.6) |
14.04 [12.00–16.24] |
|
|
CXCR2 (+1208C/T, rs1126579) |
CC | 9 (28.1) |
11.28 [8.61–12.87] |
14 (34.1) |
12.30 [7.92–15.21] |
9 (25.0) |
17.89 [10.43–20.87] |
17 (39.5) |
15.09 [12.29–23.91] |
7 (43.8) |
15.36 [12.29–24.63] |
10 (37.0) |
14.88 [9.16–23. 91] |
| CT | 17 (53.1) |
9.09 [7.52–11.43] |
18 (43.9) |
11.57 [6.47–15.17] |
20 (55.6) |
14.00 [8.63–23.52] |
21 (48.9) |
13.16 [11.43–16.24] |
7 (43.8) |
14.18 [9.86–30.99] |
14 (51.9) |
13.16 [11.43–16.24] |
|
| TT | 6 (18.8) |
11.43 [10.86–12.50] |
9 (22.0) |
6.99 [5.66–11.02] |
7 (19.4) |
12.00 [4.39–18.57] |
5 (11.6) |
16.69 [13.49–20.27] |
2 (12.4) |
18.48 [16.69–20.27] |
3 (11.1) |
13.49 [12.00–31.74] |
|
* Genotypes are known only in 152 participants as one DNA sample was of poor quality.