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. 2018 Oct 18;19(10):3221. doi: 10.3390/ijms19103221

Figure 3.

Figure 3

α-Hed altered the lysosomal pH and inhibited lysosomal cathepsin maturation. (A) α-Hed altered the lysosomal pH. Cells were treated with vehicle, α-Hed (12.5 μM), or Baf (0.1 μM) for 24 h. (B,C) α-Hed promoted mature cathepsin D (CatD) accumulation in a dose- and time-dependent manner. NCI-H1299 and NCI-H1650 cells were treated with α-Hed (12.5 μM) or Baf (0.1 μM) for the indicated time courses (C), or treated with α-Hed or Baf at the indicated doses for 24 h (B). Mature CatD was quantified and the fold increase is presented. * p < 0.05, *** p < 0.001.