Table 2.

Analysis of hydrophobic pockets present in the hDKC1 model by FPocket software.

Pocket	Relevance (%)	Volume (Å3)	Residue Number
1	100	615	96, 101, 102, 103, 122, 123, 124, 125, 126, 128, 129, 130, 131, 132, 153, 187, 188, 246, 248
2	94	203	299, 300, 301, 314, 315, 317, 320, 322, 323, 350, 354, 355, 358, 360, 361, 362, 363
3	79	284	81, 85, 88, 89, 138, 289, 290, 341, 342, 370, 371, 372, 375
4	69	926	259, 260, 261, 265, 272, 280, 281, 284, 285, 287
5	69	289	141, 142, 144, 145, 293, 296, 332, 333, 334, 344, 345, 346, 367, 368, 370
6	64	810	74, 75, 76, 80, 81, 82, 85, 88, 341, 372, 375
7	60	208	54, 91, 93, 254, 258, 259, 261, 284, 285, 287, 288, 289, 291, 292,
8	60	444	70, 71, 72, 303, 304, 307, 376, 377, 378, 379, 380,
9	58	100	157, 169, 170, 173, 204, 206, 207, 214, 215, 216, 233
10	57	367	98, 127, 129, 154, 155, 156, 215, 245, 246, 247, 249, 256
11	57	994	183, 184, 185, 186, 192, 227, 228, 231, 241, 242, 243
12	54	525	54, 55, 57, 58, 294, 295, 296, 297, 298, 324
13	47	580	301, 302, 304, 305, 308, 309, 313, 314, 315, 316, 318, 319, 378
14	47	158	53, 54, 55, 56, 77, 78, 79, 80, 290, 339, 340
15	44	92	83, 86, 87, 273, 278, 279, 282, 283
16	42	146	176, 180, 181, 182, 197, 199, 218, 220, 224, 225, 226, 228, 229, 232
17	40	295	103, 119, 120, 121, 122, 123, 124, 143, 147, 151, 222, 223
18	37	268	98, 125, 126, 127, 128, 187, 227, 243, 244, 245, 246
19	33	274	156, 206, 207, 208, 211, 213, 214, 215
20	32	425	83, 84, 87, 113, 114, 115, 137, 270, 273, 274, 282
21	28	374	138, 141, 310, 311, 369, 371, 372, 373, 374