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Regulation of the ATP-sensitive potassium channel (mitoKATP) activity by NO. The activity of the channel is stimulated (+) directly by NO (gasotransmitter shown in the dotted box). Independently, NO could stimulate sGC/cGMP/PKG pathway leading to channel phosphorylation and activation. Abbreviations: PKG, cGMP-dependent protein kinase; sGC, soluble guanylate cyclase.
