Table 1.

Phenotype in mice with deficiencies in genes related to the exocytosis process.

Gene Name	Mutant Mouse Phenotype			Reference
	Salivary Acinar Cells	Lacrimal Acinar Cells	Pancreatic Acinar Cells
Vamp8	Accumulation of secretory vesicles	Accumulation of secretory vesicles	Accumulation of secretory vesicles	[20]
Syntaxin2	Not studied	Not studied	Increased exocytosis	[21]
Rab3d	Enlarged secretory vesicles	Enlarged secretory vesicles	Enlarged secretory vesicles	[22,23]
		Decreased total protein amount in tears
Rab27a	Not studied	Increased total protein amount in tears	Not studied	[23,24]
Rab27b	Not studied	Reduced number of secretory vesicles	Not studied	[23,24]
		Increased total protein amount in tears
Noc2	Accumulation of enlarged secretory vesicles	Not studied	Accumulation of enlarged secretory vesicles	[25,26]
Sec23b	Gland degeneration	Not studied	Gland degeneration	[27,28,29]
	Absent or reduced number of secretory vesicles		Absent or reduced number of secretory vesicles