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Selenium induces endoplasmic reticulum (ER) stress response in normal and malignant cells. (a) Concentration-dependent increase in ER stress proteins and decrease in caspase-8 in peripheral blood mononuclear cells (PBMCs) with 2.5, 5 and 15 µM methylseleninic acid (MSA) at 6 h; (b) Concentration-dependent increase in both ER stress proteins and caspase-8 in THP1 cells; (c,d) Quantification of protein expression in PBMC and THP1 cells.
