Table 1.

Overview of our patient cohort, the two subgroups of clonal evolution (stepwise accumulation and catastrophic event) and examples of karyotypes for each subgroup and route of clonal evolution.

Total Cohort
Patients with del(5q)		1684
Patients with acquired additional aberrations at the time of diagnosis/during follow-up		161
Patients with clonal evolution within the del(5q) clone		134
Patients with independent clones		27
Subcategories
Isolated Del(5q)	Number	Example
Initial cytogenetic status at first time point	112/134	46,XX,del(5)(q14q34)[14]/46,XX[6]
Stepwise accumulation of cytogenetic events	70
-Not resulting in complex karyotypes	58	46,XX,del(5)(q14q34)[3]/47,idem,+21[17]
-Resulting in complex karyotypes	12	46,XX,del(5)(q14q34)[3]/47,idem,+21[10]/47,idem,del(12)(p12p13),+21[7]
Catastrophic event *	42	46,XX,del(5)(q14q34)[3]/44,idem,-7,dic(8;17)(p11;p11),del(12)(p12p13),-18[17]
Del(5q) and One Additional Aberration	Number	Example
Initial cytogenetic status at first time point	22/134	46,XX,del(5)(q14q34),del(20)(q12q13)[11]/46,XX[9]
Stepwise accumulation of cytogenetic events	12
-Not resulting in complex karyotypes	0
-Resulting in complex karyotypes	12	46,XX,del(5)(q14q34),del(20)(q12q13)[4]/46,idem,del(11)(q14) [16]
Catastrophic event *	10	46,XX,del(5)(q14q34),del(20)(q12q13)[5]/46,idem,t(4;16)(q32;q12),del(7)(q21q31),+8,-17,add(22)(q12) [15]

* defined as acquisition of two or more cytogenetic changes at the same time, automatically resulting in a complex karyotype. Deletion of 5q: del(5q).