Figure 1.

The levels and location of γ-tubulin protein that influences the proliferation capacity of mammalian cells. Schematic representation [22] showing how changes in the levels of the γ-tubulin protein (γ-tubulin 1 and γ-tubulin 2) in different cell compartments affect a proliferating cell. Cells with γ-tubulin levels of >50% divide normally, whereas those with levels of <50% arrest in interphase and ultimately die of apoptosis. Thereafter, selective depletion of γ-tubulin 1 protein reduces the pool of centrosome-associated protein, which leads to mitotic arrest due to impaired centrosome duplication and aberrant mitotic spindles.