Table 3.
Clinical trials with BMMNCs for cardiac regeneration.
| Reference | Clinical Trial | Disease | Delivery Method | Subjects | LVEF Improvement |
|---|---|---|---|---|---|
| Hamano [72] | Phase I | ICM | IM | Treated: 5 | Not shown |
| Strauer [70] | Phase I | AMI | IC | Treated: 1 0Control: 10 |
Yes |
| Assmus [65] Leistner [73] |
TOPCARE-AMI | AMI | IC | Treated: 59 | Yes |
| Wollert [66] | BOOST | AMI | IC | Treated: 3 0Control: 30 |
Yes |
| Lunde [74] | ASTAMI | AMI | IC | Treated: 24 Control: 25 |
Not shown |
| Schachinger [67] | REPAIR-AMI | AMI | IC | Treated: 101 Control: 103 |
Yes |
| Surder [68] Suerder [75] |
SWISS-AMI | AMI | IC | Treated: 128 Control: 64 |
No |
| Wohrle [76] | SCAMY | AMI | IC | Treated: 29 Control: 13 |
No |
| Strauer [77] | STAR-heart | ICM | IC | Treated: 191 Control: 200 |
Yes |
| Traverse [69] | The TIME Study | AMI | IC | Treated: 79 Control: 41 |
No |
ICM: ischemic cardiomyopathy; IM: intramyocardial injection; AMI: acute myocardial infarction; IC: intracoronary infusion.