Table 7.
Clinical trials with UC-MSCs for cardiac regeneration.
| Reference | Clinical Trial | Disease | Delivery Method | Subjects | LVEF Improvement |
|---|---|---|---|---|---|
| Li [134] | - | ICM | IC | Treated: 15 | No control |
| Musialek [135] | - | AMI | IC | Treated: 10 | No control |
| Fang [133] | - | ICM | IV | Treated: 3 | No control |
| Zhao [138] | - | ICM | IM | Treated: 3 0Control: 29 |
Yes |
| Gao [137] | Phase II | AMI | IC | Treated: 58 Control: 58 |
Yes |
| Can [139] | HUC-HEART | ICM | IM | Treated: 18 Control: 4 |
Not shown |
| Bartolucci [136] | RIMECARD | ICM | IV | Treated: 15 Control: 15 |
Yes |
ICM: ischemic cardiomyopathy; IC: intracoronary infusion; AMI: acute myocardial infarction; IV: intravenous injection; IM: intramyocardial injection.