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Model of Th17-TFH-B-cell Axis in MS. Th17 cells infiltrate the CNS, secrete IL-17, and induce inflammation. (1) Th17 responses drive the production of the chemokine CXCL13 which will facilitate the trafficking of TFH cells into the CNS. (2) Once in the CNS, TFH cells secrete IL-21 and other factors to promote ectopic follicles and pathogenic B-cell responses. (3). Figure prepared using Motifolio, Toolkit (Motifolio Inc, MD, USA).
