Table 1.

Mutations associated with resistance to FLT3 inhibitors.

FLT3 Inhibitor	Class, Type	Mutation/Amino Acid Change	Tyrosine Kinase Domain
PKC412 (Midostaurin)	First generation; Type 1	N676K [24] 672E [23] N676D [25,142] F691L, G697R [25] N676I, N676S, F691I [142]	TKD1
Sunitinib	First generation; Type 1	A627P, F691L [33] D835Y [31] Y842C [33]	TKD1 TKD2
Lestaurtinib	First generation; Type 1	A627P [33]	TKD1
Sorafenib	First generation; Type 2	F691L [31,33,142] A627P [33] D835H [31,143] D835V/F/I/del/Y/A [143] F691I, Y842N [142] Y842C [33]	TKD1 TKD2
Tandutinib	First generation; Type 2	D835Y [144]	TKD2
Quizartinib	Second generation; Type 2	F691L [31,33,73] A627P [33] D835V/F/I/del/Y [31,73,143] D835H [31] Y842C/H [73]	TKD1 TKD2
Gilteritinib	Second generation, Type 1	F961L [145,146]	TKD1
Crenolanib	Second generation, Type 1	F691L [147]	TKD1