Table 3.
Analytical and functional respiratory tests according to alpha 1 antitrypsin genotype
| PI*MM (n = 503) | PI*MS (n = 110) | PI*MZ (n = 15) | PI*SS (n = 14) | PI*SZ (n = 6) | P value* | |
|---|---|---|---|---|---|---|
| FEV1 (l) | 0.23 | |||||
| Median (IQ25–75) | 2.9 (2.5–3.4) | 2.9 (2.4–3.4) | 2.9 (2.7–3.3) | 3.1 (2.8–3.7) | 3.3 (3.2–3.3) | |
| FEV1 (%) | 0.0763 | |||||
| Median (IQ25–75) | 90 (81–100) | 91 (76–101) | 92 (84–105) | 97 (86–99) | 101 (99–111) | |
| Total IgE (IU/dL)§ | 0.194 | |||||
| Median (IQ25–75) | 272 (124–576) | 207 (74–538) | 165 (115–399) | 151 (127–646) | 169 (90–582) | |
| IgE Dermatophagoides pteronyssinus | 0.372 | |||||
| Median (IQ25–75) | 45 (17–100) | 31 (9–101) | 70 (11–101) | 34 (20–89) | 61 (30–101) | |
| IgE Dermatophagoides farinae | 0.273 | |||||
| Median (IQ25–75) | 29 (12–80) | 17 (6.6–54) | 41 (14–79) | 24 (8.8–74) | 31 (21–84) | |
| IgE Blomia tropicalis | 0.89 | |||||
| Median (IQ25–75) | 7 (2.1–22) | 8 (2.5–19) | 6 (5.2–9.6) | 9.5 (2–18) | 4.5 (1–8.5) | |
| IgE Lepidoglyphus destructor | 0.348 | |||||
| Median (IQ25–75) | 2 (1–6) | 3.1 (1.1–8) | 4 (3.6–10) | 4 (2–8) | 2.2 (2–16) | |
| IgE Tyrophagus putrescientae | 0.409 | |||||
| Median (IQ25–75) | 2.3 (1–8) | 2.3 (1.4–5) | 1 (1–1.01) | 1.6 (0.7–8) | 2.1 | |
| IgE Acarus siro | 0.129 | |||||
| Median (IQ25–75) | 2 (0.9–7) | 4 (3–5) | 10 (4.3–35) | 5.5 (1–11) | 23.3 | |
| IgA (mg/dL)§ | 0.333 | |||||
| Median (IQ25–75) | 216.5 (164–285) | 204 (150.8–261) | 261 (181–331) | 224 (193–238) | 255 (160–267) | |
| Eosinophils (109/L)§ | 0.0228‡ | |||||
| Median(IQ25–75) | 0.3 (0.2–0.5) | 0.3 (0.2–0.4) | 0.4 (0.3–0.6) | 0.5 (0.3–0.6) | 0.3 (0.2–0.4) | |
| Nasal cytology eosinophils (%) | 0.378 | |||||
| Median (IQ25–75) | 40 (10–70) | 20 (7.5–60) | 45 (33–65) | 50 (30–65) | 50 | |
| AAT (mg/dL)§ | 1.18e−25‡ | |||||
| Median (IQ25–75) | 138 (123–159) | 116 (104–137) | 80 (78–87) | 89 (86–96) | 64 (61.3–70.5) | |
FEV1 (forced expiratory volume in the 1 s), IgE (immunoglobulin E), IgA (immunoglobulin A), AAT (alpha1 antitrypsin)
* Kruskal–Wallis statistic analysis
‡Statistical significance, p value < 0.05
§Normal value IgE: 10–179 IU/ml; Normal value of IgA: 80–310 mg/dl; Normal value of blood eosinophils: 0–0.54 × 109/L; Normal value ATT: 100–200 mg/dL (1.0–2.0 g/L)