Table 1.

Comparative intrinsic activity: Range (mg/l) of MIC₅₀ and MIC₉₀ from published studies

	References	Amoxicillin/clavulanic acid		Cefuroxime		Cefditoren
		MIC50	MIC90	MIC50	MIC90	MIC50	MIC90
Streptococcus pyogenes a	13–15	≤0.012–0.06	≤0.012–0.12	0.03–0.06	0.12	≤0.03	≤0.03–0.06
Streptococcus pneumoniae b	14,15,41–48
Penicillin-susceptible		≤0.015–0.06	0.03–0.25	≤0.03	0.12–0.25	≤0.015	≤0.03–0.06
Penicillin-intermediate		0.25–1	1–4	0.5–4	4–8	0.06–0.25	0.25–0.5
Penicillin-resistant		2 - ≥16	8 - ≥16	4–8	8–32	0.25–0.5	0.5–1
Haemophilus influenzae
β-lactamase negative	14,15,22,41,44	0.25–1	1–8	0.25–2	1–8	≤0.08	≤0.03–0.06
β-lactamase positive	14,15,22,41,44	0.5–2	2–4	1–2	2–8	≤0.08	≤0.03–0.06
BLNAR	14,15,65	2	4	0.5–4	2–16	≤0.08	0.03–0.06
BLPACR	65	4	8	4	16	0.03	0.06
Moraxella catarrhalis (β-lactamase positive)	14,15,22,23	0.12–0.5	0.25–2	1	2–8	0.06–0.12	0.25–0.5

^aIn terms of ampicillin (ref. [13])

^bIn terms of amoxicillin (ref. [14, 15, 43–46])