Table 3.
Ranges of susceptibility against penicillin-susceptible (≤0.06 mg/l), penicillin-intermediate and penicillin-resistant (≥2 mg/l) pneumococcal isolates, calculated with MIC distributions from published studies [41–45] by applying CLSI breakpoints (amoxicillin, cefuroxime) and the three proposed breakpoints for cefditoren
| Antibiotic | Penicillin susceptible isolates | Penicillin intermediate isolates | Penicillin resistant isolates |
|---|---|---|---|
| Amoxicillina (≤2 mg/l) | 100% | 78.4–100% | 17.5–76% |
| Cefuroxime (≤1 mg/l) | 99.7–100% | 33.8–67.6% | 0–0.4% |
| Cefditoren | |||
| ≤ 0.125 mg/l | 99.1–100% | 37.2–71.2% | 0–0.4% |
| ≤ 0.25 mg/l | 100% | 67.6–88.6% | 15.2–57.3% |
| ≤ 0.5 mg/l | 100% | 99.3–100% | 95.3–100% |