Table 1:

Overexpression of SCAP/SREBPs in human cancers and testing their role in cancer animal models

Target	Overexpression in human cancer	References	Animal Model	Refernces
SCAP	No report	N/A	GBM xenograft mouse models by overexpression, shRNA knockdown or mutation of SCAP	[77, 108]
			SCAP knockout in diethylnitrosamine-induced mouse hepatocellular carcinoma (HCC)	[138]
SREBP-1	GBM	[60, 61]	Testing the effects of knockdown of SREBP-1 by shRNA in mouse
	Prostate cancer	[63]	xenograft models:
	Endometrial cancer	[64]	GBM	[78, 108, 139]
	HCC	[67]	Endometrial cancer	[64]
	Ovarian cancer	[68]	Ovarian cancer	[68]
	Pancreatic cancer	[69]	Pancreatic cancer	[69]
	Breast cancer	[65, 66]	Colon cancer	[140]
SREBP-2	Prostate cancer	[73]	SREBP-2 xenograft model by shRNA knockdown in
			GBM	[108]
			Prostate cancer	[73]
			Colon cancer	[140]