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. Author manuscript; available in PMC: 2019 Mar 13.
Published in final edited form as: Small Methods. 2018 Feb 7;2(3):1700318. doi: 10.1002/smtd.201700318

Figure 2.

Figure 2.

Macrobioprinting of vascularized bone niche and cardiac patch. A) Vascularized bone constructs were fabricated as pyramidal constructs hosting a perfusable vascular lumen lined with HUVECs (pink) and array of hMSCs-laden VEGF-functionalized GelMA fibers with different mechanical strengths. B) Imaging of cross section of the resulting scaffold. C) Imaging of cross-sectional fluorescence gradient to show different chemical functionalization of bioprinted fibers. Scale bars in (B) and (C) are 500 μm. A–C) Adapted with permission.[36] Copyright 2017, Wiley-VCH. D) Bioprinting design of prevascularized cardiac patches, E) where a PCL layer provides structural support for F) two cell-laden bioinks. Scale bar in (E) (left) is 1 mm, while the scale bar in (F) is 200 μm. D–F) Adapted with permission.[39] Copyright 2017, Elsevier.