Table 7.
Selection approach | No of SNPs selected | Training set (419) | Testing set (n = 204) | |
---|---|---|---|---|
Original c-index | Corrected c-index* | c-index* (95% CI) | ||
ISIS-LASSO | 2 | 0.649 | 0.646 | 0.664 (0.621–0.707) |
ISIS-ALASSO | 0 | 0.649 | 0.650 | 0.671 (0.624–0.719) |
ISIS-RSF | 2 | 0.650 | 0.645 | 0.669 (0.618–0.720) |
SIS | 2 | 0.650 | 0.646 | 0.669 (0.624–0.714) |
SIS-LASSO | 0 | 0.649 | 0.649 | 0.671 (0.626–0.717) |
SIS-ALASSO | 0 | 0.649 | 0.650 | 0.671 (0.620–0.723) |
SIS-RSF | 2 | 0.650 | 0.648 | 0.669 (0.623–0.716) |
PSIS | 40 | 0.749 | – | 0.572 (0.527–0.617) |
PSIS-LASSO | 28 | 0.746 | 0.727 | 0.568 (0.524–0.613) |
PSIS-ALASSO | 24 | 0.744 | 0.727 | 0.573 (0.528–0.617) |
PSIS-RSF | 35 | 0.748 | – | 0.575 (0.529–0.622) |
LASSO | 16 | 0.716 | – | 0.586 (0.540–0.632) |
ALASSO | 13 | 0.653 | 0.634 | 0.647 (0.601–0.693) |
*Based on 200 bootstrapped samples