Table 1.
Effector cell molecule | DC-rAAV/AFP | Dex | DC-Dex | Non-transfected DCs |
---|---|---|---|---|
CD45RO | 35.46±1.56a,b | 32.24±4.58a,b | 53.83±3.05a | 24.96±0.53 |
CD45RA | 40.46±7.94a,b | 32.63±0.95a | 27.8±3.3a | 54.33±2.9 |
CD11a/CD244 | 56±2.49a,b | 50.93±3.41a,b | 70.06±3.49a | 42.86±6.01 |
CD28 | 49.3±1.15 | 49.83±3.22 | 56.1±2.87a | 43.96±0.98 |
OX40 | 15.79±3.86 | 21.47±7.66 | 28.06±2.67a | 10.35±3.25 |
HLA-DR | 53.83±3.53 | 55.16±3.78 | 59.36±5.78a | 52.56±4.71 |
CD69 | 4.08±0.61 | 5.3±1.31 | 7.06±0.86 | 4.53±1.55 |
CD71 | 63.9±3.98 | 61.26±4.99 | 64.53±6.84 | 57.26±4.84 |
CD95 | 52.3±3.28 | 54.61±2.74 | 55.95±4.62 | 48.86±3.12 |
PD-1 | 8.69±1.21b | 13.94±2.11 | 17.67±2.4a | 8.63±1.48 |
CTLA-4 | 1.26±0.06 | 1.27±0.17 | 1.4±0.28 | 1.38±0.05 |
CD8/GrB | 53.56±1.67a,b | 57.36±1.35a | 61.5±1.17a | 43.36±2.48 |
CD8/perforin | 31.96±1.79a,b | 32.2±0.46a,b | 37.6±1.53a | 19.46±1.47 |
Notes:
P<0.05 vs non-transfected DCs;
P<0.05 vs DC-Dex.
Abbreviations: AFP, alpha-fetoprotein; DC, dendritic cell; Dex, dendritic cell-derived xosome; rAAV, recombinant adeno-associated viral vector.