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. 2018 Oct 26;5:153. doi: 10.3389/fcvm.2018.00153

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Copyright © 2018 Patil, Le, Sligar, Mei, Chavarria, Yang and Baker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of fucoidan on atherosclerosis and hepatic lipid metabolism. ApoE^shl mice were treated under control conditions (NFD), with a high fat diet (HFD), and a high fat diet with 1% and 5% fucoidan for 12 weeks (n = 6). (A) Oil-red O staining of intima of thoracic aorta to show atherosclerotic lesions. (B) Quantification of lesion area to total aorta calculated using ImageJ. The thickness of the intima was normalized to the thickness of the media to calculate the percentage of plaque. (C) Appearance of liver. (D–F) Total cholesterol, triacylglycerol and 4-hydroxynonenal concentrations in liver. Values are mean. ^*p < 0.05 vs. HFD. Modified and used with permission (11).