Table 2.

Odds of orthostatic hypotension or orthostatic tachycardia by contrasts in blood pressure goal and initial medication, N = 1,090 (number of post-randomization visits was 48,918)

	OR (95% CI)
Contrast	Drop in SBP of ≥20 mm Hg, N = 715 visits	Drop in DBP of ≥10 mm Hg, N= 494 visits	Rise in HR of ≥20 beats per minute, N = 1,879 visits	Consensus Definition: Either BP Criteria, N = 1,005 visits	Any Criteria (SBP, DBP, or HR), N = 2,824 visits
Intensive vs Standard	0.84 (0.58, 1.22)	0.89 (0.60, 1.30)	1.10 (0.90, 1.35)	0.93 (0.68, 1.28)	1.05 (0.88, 1.26)
Metoprolol vs Ramipril	1.71 (1.15, 2.53)*	1.43 (0.96, 2.15)	0.44 (0.35, 0.55)*	1.58 (1.14, 2.20)*	0.72 (0.59, 0.88)*
Amlodipine vs Ramipril	0.91 (0.50, 1.65)	1.26 (0.74, 2.14)	0.96 (0.74, 1.23)	1.05 (0.65, 1.68)	0.97 (0.76, 1.23)
Metoprolol vs Amlodipine	1.88 (1.04, 3.41)*	1.14 (0.65, 1.99)	0.46 (0.35, 0.60)*	1.51 (0.93, 2.44)	0.74 (0.58, 0.96)

Note: Participants were assigned to one of six interventions: intensive-ramipril, intensive-metoprolol, intensive-amlodipine, standard-ramipril, standard-metoprolol, or standard-amlodipine. Models were adjusted for initial medication in the blood pressure goal comparisons, and adjusted for blood pressure goal in the initial medication comparisons.

^*P < 0.05