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. Author manuscript; available in PMC: 2018 Nov 2.
Published in final edited form as: J Heart Health. 2018 Apr 25;4(1):10.16966/2379-769X.146. doi: 10.16966/2379-769X.146

Figure 3.

Figure 3

Prevention and suppression of acute oxidative AF with the CaMKII inhibitor KN-93 (1 μM). Pretreatment with KN-93 prevents emergence of H2O2-induced AF over a 50 min of observation (panel A). However, subsequent replacement of KN-93 with its inactive form, KN-92 (1 μM) causes AF to emerge within 6 minutes of the switch (panel B). Note below the panel B a faster sweep recording showing the onset of AF (arrow) followed immediately by VF. Panel C shows another aged heart in which the AF was initiated with H2O2 (0.1 mM) and was effectively suppressed by the addition of KN-93(1 μM) in the continuous presence of H2O2