REAGENT or RESOURCE	SOURCE		IDENTIFIER
Antibodies
anti-full-length AR (AR-FL) C-terminus (C19)	Santa Cruz Biotechnology		catalog # sc-815X
anti-AR-V7 C-terminus specific	Precision Antibody		AG10008
anti-pan-AR N-terminus (N20)	Santa Cruz Biotechnology		sc-816
anti-BRD4 ChIP Grade	Bethyl		A301–985A100
Mouse anti-Flag tag (M2)	Sigma		F1804
Mouse Anti-HA tag antibody - ChIP Grade	Abcam		ab9110
Anti-HA HA.11 (16B12)	Covance		MMS-101 P-200
anti-ZFX	Thermo Fisher		PA5–34376
anti-ZFX	Chen et al., 2008		NA
Mouse anti-ZFX	Cell Signaling		mAb #5419
anti-Tubulin (DM1A) Mouse mAb	Cell signaling tech.		3873S
anti-FOXA1 ChIP Grade	Abcam		23738
goat anti-mouse IgG HRP	Santa Cruz Biotechnology		sc-2005
goat anti-rabbit IgG-HRP	Santa Cruz Biotechnology		sc-2004
Dynabeads™ M-280 Sheep Anti-rabbit IgG	Thermo Fisher Scientific		11203D
Dynabeads™ M-280 Sheep Anti-Mouse IgG	Thermo Fisher Scientific		11202D
Dynabeads™ Protein G for Immunoprecipitation	Thermo Fisher Scientific		10003D
Bacterial and Virus Strains
DH5a E.coli competent cells	Thermo Fisher Scientific		catalog # 18265017
One Shot TOP10 Chemically competent E.coli	Thermo Fisher Scientific		catalog # sc-2004
Chemicals, Peptides, and Recombinant Proteins
Dihydrotestosterone (DHT)	Sigma-Aldrich		Catalog # D-073; CAS: 521–18-6
Enzalutamide (MDV3100)	Selleck chemical		Catalog #.S1250; CAS: 915087–33-1
(+)-JQ1 BET bromodomain inhibitor	Selleck chemical		S7110; CAS: 1268524–70-4
I-BET151 (GSK1210151A) BET inhibitor	Selleck chemical		S2780; CAS: 1300031–49-5
UltraPure™ 10mg/mL Ethidium Bromide	Invitrogen		15–585-011
Polybrene	Sigma		TR-1003-G
PMSF	Sigma-Aldrich		78830
Glycine	Sigma		G8898
Retro-X Concentrator	Clontech		631455
16% Paraformaldehyde	Electron Microscopy Sciences		15710
Lipofectamine 3000 Transfection Reagent	Thermo Fisher Scientific		L3000150
Lipofectamine 2000 Transfection Reagent	Thermo Fisher Scientific		11668–019
Protease inhibitor COMPLETE EDTA-FREE	Roche		11873580001
T4 DNA Ligase	New England Biolabs		M0202S
Proteinase K	Thermo Fisher Scientific		BP1700–500
Rnase A	Sigma-Aldrich		R4875
Thiazolyl Blue Tetrazolium Blue	Sigma-Aldrich		M2128
Critical Commercial Assays
RNeasy Plus Mini Kit (250)	Qiagen		74136
iSCRIPT cDNA Synthesis KIT	Biorad		1708891
iTaq Universal SYBR Green Supermix	Biorad		1725125
SsoAdvanced™ Universal SYBR® Green Supermix	Biorad		172–5270
Bio-Rad Protein Assay Dye Reagent Concentrate	Biorad		5000006
MycoAlert™ PLUS Mycoplasma Detection Kit	Lonza		LT27–286
MycoZap™ Plus-CL	Lonza		VZA-2012
Beckman Coulter AMPURE XP PCR Purification	Beckman Coulter		A63881
TruSeq RNA Library Preparation Kit v2, Set A	Illumina		RS-122–2001
TruSeq RNA Library Preparation Kit v2, Set B	Illumina		RS-122–2002
End-It™ DNA End-Repair Kit	Epicentre		ER81050
NEBNext Multiplex Oligos for Illumina (Index Primers Set 1)	New England Biolabs		E7335S
CellTiter 96 AQueous One Solution Cell Proliferation Assay	Promega		G3580
QuikChange II XL Site-Directed Mutagenesis Kit	Agilent		200521
SureBeads™ immunoprecipitation Kit with protein A and G conjugated magnetic beads	Biorad		161–4833
Restore™ Western Blot Stripping Buffer	Thermo Scientific		21059
BD Matrigel™ Basement Membrane Matrix	BD Biosciences		354234
Deposited Data
Raw and analyzed data	This paper		GEO: GSE94013
Unprocessed immunoblotting image data (deposited as Mendeley DOI link)	This paper		htto://dx.doi.org/10.17632/vmmrvbnd4.2
TCGA-PRAD dataset (RNA-seq of 543 samples)	Cancer Genome Atlas Research, 2015		https://portal.gdc.cancer.gov/projects/TCGA-PRAD
Beltran et al study of prostate cancer	(Beltran et al., 2016)		dbGAP:pht004946.v1.p1
Yu et al. study of prostate cancer	Yu et al., 2004		GEO GSE68555
Taylor et al. study of prostate cancer	(Taylor et al., 2010)		GEO GSE21034
Varambally et al study of prostate cancer	Varambally et al., 2008		GEO GSE3325
Experimental Models: Cell Lines
22Rv1 cells	ATCC		CRL-2505
VCaP cells	ATCC		CRL-2876
LNCaP cells	ATCC		CRL-1740
HEK293 cells	ATCC		CRL-1573
HEK293T cells	ATCC		CRL-3216
Experimental Models: Organisms/Strains
NSG; NOD/scid/ IL2Rgamma-null	Jackson Laboratory		Strain: 005557
Oligonucleotides
shRNA for specific knockdown of AR-FL or AR-V7	Guo et al., 2009		N/A
RT q-PCR oligos	This paper; see Table S6		N/A
ChIR-qPCR oligos	This paper; see Table S6		N/A
ON-TARGETplus SMART-pool siRNA of ZFX	GE Dharmacon		N/A
ON-TARGETplus SMART-pool siRNA of FOXA1	GE Dharmacon		N/A
recommended control siRNAs	GE Dharmacon		N/A
Recombinant DNA
MSCV-HA-AR-V7	This paper		N/A
pcDNA AR-FL and deletion construct	Zhou et al 1995;		N/A
Plasmid: MSCV neo; MSCV puro	Clonetech		634401
Plasmid: pCDNA3.1	Thermo Scientific		V79520
Software and Algorithms
BWA (V0.7.12) alignment software	(Li and Durbin, 2010)		https://sourceforge.net/projects/bio-bwa/
Samtools	Li et al., 2009		http://samtools.sourceforge.net/
MACS2 & MACS1.4.2	Zhang et al., 2008		https://github.com/taoliu/MACS
seqMiner	Ye et al., 2011		https://sourceforge.net/projects/seqminer/
Java treeview	n/a		https://sourceforge.net/projects/jtreeview/
Genomic Regions Enrichment of Annotations Tool (GREAT)	n/a		http://bejerano.stanford.edu/great/public/html/index.php
HOMER	Heinz et al., 2010		http://homer.ucsd.edu/homer/
MEME-ChIP	Machanick and Bailey, 2011		http://meme-suite.org/doc/meme-chip.html
MapSplice	Wang et al., 2010		https://sourceforge.net/projects/mapsplice/
STAR	(Dobin et al., 2013)		https://github.com/alexdobin/STAR
RSEM	Li and Dewey, 2011		https://www.encodeproject.org/software/rsem/
DESeq/DESeq2	(Anders and Huber, 2010; Love et al., 2014)		https://software.broadinstitute.org/gsea/index.jsp
IGV Browser	(Robinson et al., 2011)		https://software.broadinstitute.org/software/igv/
GSEA 2–2.2.0 software	(Subramanian et al., 2005)		https://software.broadinstitute.org/gsea/index.jsp
Other