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Reduced interaction of compound CX06 with a capsid hexamer mutant Q63A. The interaction of compound CX06 (25 μM) and control compound PF-74 (10 μM) with wild-type and mutant Q63A capsid hexamer in SPR. Both responses in wild-type and mutant Q63A were normalized to the theoretical Rmax as percent maximal response. Data shown are mean values of three individual experiments done in triplicate, with error bars depicting the standard error of the mean (SEM) (p<0.005).
