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(A) The individual models that comprise the modified oral non-CNS (central nervous system) drug profile and their respective importance to the profile. HIA = human intestinal absorption; hERG (human ether-à-go-go-related gene); IC50 = half-maximal inhibitory concentration; BBB = blood–brain barrier.(B) Plot showing the StarDrop (Optibrium, Ltd., Cambridge, UK)– derived logS versus the score from a multimetric, modified oral non- CNS profile for PF-74 and the CX compounds.
