Table 1. Summary of phenotypes observed in global AHR-KO mice.
Phenotypes Observed in Global AHR-KO mice |
Increased numbers of peripheral white blood cells |
Alterations in white blood cell subsets |
Elevated HSC oxidative stress elevated |
HSC DNA damage increased |
HSC p16 expression decreased |
Spleen weight increased |
Decreased HSC self-renewal during serial transplants |
672 genes altered compared to WT using microarray |