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. 2018 Nov 2;13(11):e0206552. doi: 10.1371/journal.pone.0206552

Fig 4. Suppression of G0S2 improved the survival rate in a glioma xenograft model.

Fig 4

(a) Lenti-G0S2 shRNA-infected U87 with knocked down gene expression. n = 3. *p < 0.05 by Student’s t-test. (b) Although Lenti-G0S2 shRNA-GFP U87 cells infiltrated normal brain tissues, the outer rim of Lenti–control shRNA–GFP U87 cells became smooth. Regions of interest are enlarged in the lower panel. Scale bar: 1 mm (low-magnification, upper panel), 200 μm (high-magnification, lower panel). (c) Mice injected with U87 cells with lentiviral expression of G0S2 shRNA-GFP exhibited prolonged overall survival compared with those with control shRNA-GFP. Median OS; G0S2 shRNA (n = 9) 64.6 days, control shRNA (n = 10) 51.4 days. P = 0.0247 by log rank tests.