TABLE 2.
Statistical analysis of treatment effects in study 1
| Treatment difference: peak FEV1 L | Treatment difference: FEV1 average effect 0–8 h L | |||
| Difference (95% CI) | p-value | Difference (95% CI) | p-value | |
| Salbutamol versus placebo | 0.187 (0.142–0.232) | <0.001 | 0.123 (0.087–0.159) | <0.001 |
| Ipratropium versus placebo | 0.199 (0.153–0.244) | <0.001 | 0.165 (0.128–0.201) | <0.001 |
| RPL554 versus placebo | 0.223 (0.178–0.269) | <0.001 | 0.165 (0.133–0.206) | <0.001 |
| Salbutamol+RPL554 versus placebo | 0.292 (0.250–0.340) | <0.001 | 0.235 (0.199–0.271) | <0.001 |
| Ipratropium+RPL554 versus placebo | 0.292 (0.247–0.337) | <0.001 | 0.229 (0.192–0.265) | <0.001 |
| RPL554 versus salbutamol | 0.039 (−0.009–0.081) | 0.120 | 0.046 (0.010–0.082) | 0.0136 |
| RPL554 versus ipratropium | 0.024 (−0.021–0.070) | 0.294 | 0.004 (−0.032–0.041) | 0.8148 |
| Salbutamol versus ipratropium | −0.012 (−0.057–0.034) | 0.614 | −0.042 (−0.078–0.005) | 0.0245 |
| Salbutamol+RPL554 versus salbutamol | 0.108 (0.063–0.153) | <0.001 | 0.112 (0.076–0.148) | <0.001 |
| Ipratropium+RPL554 versus ipratropium | 0.094 (0.049–0.139) | <0.001 | 0.064 (0.028–0.100) | 0.0006 |
FEV1: forced expiratory volume in 1 s.