Figure 6.

(A) The scratching width of A549 cells was observed at 12 h after the treatment with DOX, Se@DOX, and RGDfC-Se@DOX. The scale bars are 200 µm. (B) The cell motility of control, DOX, Se@DOX, and RGDfC-Se@DOX was quantitatively analyzed. (C) The effect of DOX, Se@DOX, and RGDfC-Se@DOX on the migration of A549 cells. The scale bar is 200 µm. (D) The inhibition rate of cell migration of DOX, Se@DOX, and RGDfC-Se@DOX was quantitatively analyzed. RGDfC-Se@DOX, selenium nanoparticles conjugated with RGDfC and DOX; Se@DOX, selenium nanoparticles conjugated with DOX.

Abbreviations: DOX, doxorubicin; RGDfC, Arg–Gly–Asp–d-Phe–Cys.