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. 2018 Oct 29;11:7543–7553. doi: 10.2147/OTT.S176724

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© 2018 Xiong et al. This work is published and licensed by Dove Medical Press Limited

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Radiographs indicated the impaired proximal tibias by OSA.

Notes: (A) Thirteen days after the inoculation of tumor cells, tumor lesion in the injected proximal tibia was noticed, with osteolysis indicated by the Codman triangle (red arrow). Erosion of the affected skeleton deteriorated over time (B), and the surrounding soft tissue started to form lumps with calcification shadows 28 days postinnocuation (C). (D) The tumor lesion became completely destructive at the injected tibia at 42 days.

Abbreviation: OSA, osteosarcoma.