Figure 7.

Reduction of Ki-67 positive cells by BMP-2 treatment.

Notes: Immunohistochemical staining shows expansion of Ki-67 positive cells (brown stained) was unrestricted and became overwhelming in the collagen gel control groups (A and B). However, the expansion was then suppressed by the treated rhBMP-2 at the later time point (C and D). Scale bar =100 µm. Higher magnified regions of interest are indicated in A1–D1, with less spreading cells that are Ki-67 positive. Scale bar =60 µm.

Abbreviation: rhBMP-2, recombinant human BMP-2.