Table 4. Baseline corrected geometric mean fold ratio and frequency of response by neutralization assays at four weeks post boost.

Treatment Group	Baseline Corrected Geometric Mean Fold Ratio (GMFR) (95% CI)	p-value for GMFR	Frequency of response (%) relative to baseline (95% CI)b
A/New Caledonia/20/1999 (H1N1)
DNA-IIV3a	1.41 (1.10–1.81)	p = 0.008	9.7 (2.0–25.8)
IIV3-IIV3			0.0 (0.0–11.2)
A/South Carolina/1/1918 (H1N1)
DNA-IIV3a	1.55 (1.27–1.89)	p<0.001	35.5 (19.2–54.6)
IIV3-IIV3			19.4 (7.5–37.5)
A/Canada/720/2005 (H2N2)
DNA-IIV3a	0.96 (0.70–1.33)	p = 0.808	3.2 (0.1–16.7)
IIV3-IIV3			16.1 (5.5–33.7)
A/Beijing/353/1989 (H3N2)
DNA-IIV3a	1.23 (0.87–1.73)	p = 0.239	32.3 (16.7–51.4)
IIV3-IIV3			16.1 (5.5–33.7)
A/Hong Kong/1/1968 (H3N2)
DNA-IIV3a	1.21 (0.88–1.66)	p = 0.241	22.6 (9.6–41.1)
IIV3-IIV3			19.4 (7.5–37.5)
A/Indonesia/05/2005 (H5N1)
DNA-IIV3a	0.96 (0.83–1.11)	p = 0.559	0.0 (0.0–11.2)
IIV3-IIV3			0.0 (0.0–11.2)
A/Vietnam/1203/2004 (H5N1)
DNA-IIV3a	1.21 (0.88–1.66)	p = 0.227	12.9 (3.6–29.8)
IIV3-IIV3			6.5 (0.8–21.4)
A/Anhui/1/2013 (H7N9)
DNA-IIV3a	1.04 (0.78–1.39)	p = 0.783	3.2 (0.1–16.7)
IIV3-IIV3			3.2 (0.1–16.7)
A/Hong Kong/1073/1999 (H9N2)
DNA-IIV3a	1.28 (0.88–1.88)	p = 0.191	16.1 (5.5–33.7)
IIV3-IIV3			9.7 (2.0–25.8)
B/Brisbane/60/2008
DNA-IIV3a	1.01 (0.74–1.38)	p = 0.928	16.1 (5.5–33.7)
IIV3-IIV3			16.1 (5.5–33.7)
B/Brisbane/60/2008—microneutralization assay
DNA-IIV3a	0.94 (0.66–1.35)	p = 0.738	9.7 (2.0–25.8)
IIV3-IIV3			9.7 (2.0–25.8)
B/Wisconsin/1/2010—microneutralization assay
DNA-IIV3a	1.18 (0.78–1.78)	p = 0.421	54.8 (36.0–72.7)
IIV3-IIV3			41.9 (24.5–60.9)

p values for GMFR comparison between regimens were determined by pairwise t-test.

^aDNA injection at 4 mg.

^bPositive response rate defined as four-fold increase over baseline.