Table 4. Baseline corrected geometric mean fold ratio and frequency of response by neutralization assays at four weeks post boost.
Treatment Group | Baseline Corrected Geometric Mean Fold Ratio (GMFR) (95% CI) | p-value for GMFR | Frequency of response (%) relative to baseline (95% CI)b |
---|---|---|---|
A/New Caledonia/20/1999 (H1N1) | |||
DNA-IIV3a | 1.41 (1.10–1.81) | p = 0.008 | 9.7 (2.0–25.8) |
IIV3-IIV3 | 0.0 (0.0–11.2) | ||
A/South Carolina/1/1918 (H1N1) | |||
DNA-IIV3a | 1.55 (1.27–1.89) | p<0.001 | 35.5 (19.2–54.6) |
IIV3-IIV3 | 19.4 (7.5–37.5) | ||
A/Canada/720/2005 (H2N2) | |||
DNA-IIV3a | 0.96 (0.70–1.33) | p = 0.808 | 3.2 (0.1–16.7) |
IIV3-IIV3 | 16.1 (5.5–33.7) | ||
A/Beijing/353/1989 (H3N2) | |||
DNA-IIV3a | 1.23 (0.87–1.73) | p = 0.239 | 32.3 (16.7–51.4) |
IIV3-IIV3 | 16.1 (5.5–33.7) | ||
A/Hong Kong/1/1968 (H3N2) | |||
DNA-IIV3a | 1.21 (0.88–1.66) | p = 0.241 | 22.6 (9.6–41.1) |
IIV3-IIV3 | 19.4 (7.5–37.5) | ||
A/Indonesia/05/2005 (H5N1) | |||
DNA-IIV3a | 0.96 (0.83–1.11) | p = 0.559 | 0.0 (0.0–11.2) |
IIV3-IIV3 | 0.0 (0.0–11.2) | ||
A/Vietnam/1203/2004 (H5N1) | |||
DNA-IIV3a | 1.21 (0.88–1.66) | p = 0.227 | 12.9 (3.6–29.8) |
IIV3-IIV3 | 6.5 (0.8–21.4) | ||
A/Anhui/1/2013 (H7N9) | |||
DNA-IIV3a | 1.04 (0.78–1.39) | p = 0.783 | 3.2 (0.1–16.7) |
IIV3-IIV3 | 3.2 (0.1–16.7) | ||
A/Hong Kong/1073/1999 (H9N2) | |||
DNA-IIV3a | 1.28 (0.88–1.88) | p = 0.191 | 16.1 (5.5–33.7) |
IIV3-IIV3 | 9.7 (2.0–25.8) | ||
B/Brisbane/60/2008 | |||
DNA-IIV3a | 1.01 (0.74–1.38) | p = 0.928 | 16.1 (5.5–33.7) |
IIV3-IIV3 | 16.1 (5.5–33.7) | ||
B/Brisbane/60/2008—microneutralization assay | |||
DNA-IIV3a | 0.94 (0.66–1.35) | p = 0.738 | 9.7 (2.0–25.8) |
IIV3-IIV3 | 9.7 (2.0–25.8) | ||
B/Wisconsin/1/2010—microneutralization assay | |||
DNA-IIV3a | 1.18 (0.78–1.78) | p = 0.421 | 54.8 (36.0–72.7) |
IIV3-IIV3 | 41.9 (24.5–60.9) |
p values for GMFR comparison between regimens were determined by pairwise t-test.
aDNA injection at 4 mg.
bPositive response rate defined as four-fold increase over baseline.