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Nicotine’s promotion of aneurysm rupture requires α7*-nicotinic acetylcholine receptors. A, Incidence of aneurysms. B, Rupture rate. C, Symptom-free curve (Kaplan-Meier analysis curve). VC and α7 KO indicates vehicle control and nAChR α7 subunit knockout. *P < 0.05 vs WT + nicotine.
